Longevity Magazine A review journal of healthspan, preventative medicine and ageing
Index

Explainers

Method rather than substance. How to judge a claim, whoever is making it.

4 explainersLast checked 31 July 2026

In short

Explainers cover the reasoning that produces a grade rather than any particular intervention. They are written to be useful outside this journal: the same questions apply to any health claim you encounter, in any field, from any source.

  1. 01

    How to read a clinical trial

    Six things to check before you believe a trial. Most of them are in the parts of the paper nobody reads.

    Method
  2. 02

    Surrogate endpoints, and why they mislead

    A marker moves. Nobody gets better. This is the most reliably repeated failure in preventative medicine, and the reasoning behind it is worth understanding once.

    Method
  3. 03

    Biological age tests: what they measure

    The output is a number of years. What produced it is a statistical model trained to predict something, and which something matters enormously.

    Method
  4. 04

    Supplement regulation in the UK

    A supplement on a British shelf has not been assessed for whether it works. Understanding what the system does check is the point of this explainer.

    Method