He is a tenured professor in the Department of Genetics at Harvard's Paul F. Glenn Center for Research in the Biology of Aging. Sinclair's laboratory was the first to identify the role of NAD+ biosynthesis in regulating life expectancy, such as CR-activated sirtuins in mammals (A Unified Theory of Caloric Restriction, 200), the identification of small molecules that activate SIRT1, such as resveratrol, the way in which organisms seem to have evolved to detect plant stress and the decrease in food supply by causing plant stress metabolites, such as polyphenols, to activate the defenses of longevity (The Xenohormesis Hypothesis, 200), that the relocation of epigenetic factors such as SIRT1 in response to DNA breaks can be a cause of aging (The RCM Hypothesis of Aging, 200), how the lack of communication between the mitochondrial and nuclear genomes is a cause of age-related physiological deterioration (The Mitochondrial Oasis Hypothesis, 200) and the idea that epigenetic changes that cause cells to lose their identity are the main cause of aging and are a reversible process (The Information Theory of Aging, 201. Sinclair's past and present advisory roles, board positions, funding sources, authorized inventions, investments, funding, and invited talks. David Sinclair, biologist and anti-aging researcher at Harvard, has spent more than 53 years on the planet. He has spent several decades of those years making key discoveries in the science of longevity, creating biotechnology companies and obtaining dozens of patents.
Boosting innovation by guiding studies such as the FAST Initiative, the SuperAgers Initiative and the TAME trial Major advances driven by AFAR experts Delaying disease by focusing on aging Save costs by extending life expectancy Dr. Kirkland and several other AFAR experts have also identified another natural senolytic, fisetin, which is also found in many fruits and vegetables. Experts from Kirkland and AFAR found that it was possible to reduce senescent cell burden, extend lifespan and improve health, even when treatment was initiated late in life. The Science Daily article on senoteroeutical research led by Dr. Campisi also co-authored research on eliminating senescent cells and alleviating the causes of diabetes in obese mice.
Campisi explains his research on senescence in this video, produced by the Buck Institute for Aging. Research in Aging Cell, co-authored by Dr. Campisi and six AFAR experts who study senescent cells alleviate obesity-induced metabolic dysfunction. LeBrasseur is an associate professor and director of the Healthy Aging and Independent Living Program at the Kogod Center for Aging at the Mayo Clinic.
In this Mayo Clinic video, LeBrasseur explains studies on the impact of exercise on aging in mice. Research published in the journal Diabetes is co-author of Dr. LeBrasseur and other AFAR fellows on the effect of exercise on diet-induced cellular senescence. Okonkwo's research on Alzheimer's and exercise.
Sperling is director of the Alzheimer's Research and Treatment Center at the Massachusetts Alzheimer's Disease Research Center and professor of neurology at Harvard Medical School. Research at JAMA Neurology is co-author of Dr. Sperling on physical activity, cognitive decline and neurodegeneration. Rando's research has explored which components of young blood have this potential therapeutic benefit and they have also tried to understand what actually changes in old cells, at the molecular level, to make them appear younger.
Rando is a professor in the Department of Neurology and Neurological Sciences at Stanford University School of Medicine; director of the Glenn Center for the Biology of Aging at the Stanford University School of Medicine; and deputy director of the Stanford Center on Longevity (SCL). Rando is also member of the AFAR board of directors. New York Times article that highlights Dr. Rando's research on the role of young blood in extending life expectancy.
Ask the expert in an interview with Dr. Rando about young blood, biomarkers, and aging. Longo is director of the USC Longevity Institute, Edna M, Jones Professor of Gerontology and professor of Biological Sciences at the Leonard Davis School of Gerontology at USC. He is the author of the book The Longevity Diet.
Panda is a professor at the Salk Institute for Biological Studies, where he heads the Panda Lab. Panda's TED Talk: Health lies in healthy circadian habits. Longo, it's not what you eat, it's when. Cuervo is widely recognized in this field for her research on autophagy, a process used by cells to eliminate or recycle their waste products, including damaged proteins and organelles, and for the contribution of autophagy failure to aging and age-related diseases.
Dr. Cuervo is co-author of research at Cell on the development of drugs to revitalize autophagy and combat Alzheimer's disease Interview with Dr. Raven on autophagy, courtesy of the Albert Einstein College of Medicine. Raven on selective autophagy and aging. Dillin's research has also explored the possibility of correcting heat shock, one of the main causes of protein decay, by increasing the number of genes chaperones in the cell with the HSF-1 (heat shock factor) protein.
Dillin talks about the ribosomal perspective of proteostasis and aging in cellular metabolism, in his recent special issue on aging. Since the aging processes in mice and humans are similar, this suggests that these drugs can be formulated to prevent or alleviate multiple chronic diseases in humans. Nir Barzilai, a member of the AFAR board of directors and a recipient of multiple grants, is leading the TAME trial (aimed at aging with metformin), which will test whether metformin, a drug currently prescribed as a first line of defense against type 2 diabetes (onset in adulthood) and which millions of people are already taking, can delay the onset of age-related diseases. Thanks to the management of AFAR, TAME is now in the planning phase and will open the door to more trials based on other promising drugs.
Barzilai is the director of the Institute for Research on Aging at the Albert Einstein College of Medicine and the director of the Paul F. Glenn Institute for Research in the Biology of Human Aging and the Nathan Shock Centers of Excellence in Basic Biology of Aging at the National Institutes of Health (NIH). Barzilai, at the Barzilai conference at TEDx Boston, entitled Emerging Aging Research, emphasizes the importance of funding the TAME trial, managed by AFAR, to get the Federal Food and Drug Administration (FDA) to indicate aging in STAT News. Barzilai and AFAR experts plan the TAME trial in Breakthrough: The Age of Aging, directed by Ron Howard in the National Geographic channel.
Barzilai discusses ways to increase life expectancy and the potential of metformin in the Vogue article, Is Aging a Disease That Can Be Reversed? A look at the science behind the longevity movement In mice, the drug rapamycin has been shown to delay the onset of Alzheimer's disease and even delay normal age-related memory impairment, preserves heart function, prevents several types of cancer and improves response to the vaccine in older adults. Kaeberlein is a professor in the Department of Pathology at the University of Washington, Seattle; director of the Institute for Research on Healthy Aging and Longevity at the University of Washington; and co-director of the Nathan Shock Center of Excellence for Medicine at the University of Washington in Basic Biology of Aging. Kaeberlein explains how the Canine Aging Project is helping to improve understanding in the field of therapies that focus on the biological processes of aging to extend lifespan. At the University of Washington, Dr. Promislow is a professor in the Department of Pathology and the Department of Biology.
He is also the director of the Canine Longevity Consortium. Rabinovitch is professor and vice president of research and director of the flow cytometry laboratory at the University of Washington Medicine. Marcinek is an associate professor at the University of Washington and principal investigator of the Marcinek laboratory. The NIH at Rabinovitch funded research to test the hypothesis that mitochondria-targeting therapies are able to resist age-related diseases and improve health and function in aging mammals. Marcinek is an associate professor at the University of Washington Medicine.
Because sirtuins rely on nicotinamide adenine dinucleotide (NAD), and NAD levels halve as we age, Dr. Sinclair is currently working on NAD-boosting molecules to restore those levels from NAD to youth levels. Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.
Sinclair, Breaking and Reversing the Aging Clock. Barzilai, this is the reason why we need to start treating aging how we treat diseases. Austad is a distinguished professor and chair of the Department of Biology at the University of Alabama at Birmingham. In addition to directing the Nathan Shock Center of Excellence in Basic Biology of Aging at the UAB, Dr.
Austad is the co-principal investigator of the NSC Coordinating Center of the NIA. Austad on sex differences in life expectancy in the special issue on aging of Cell Metabolism. Austad's column for PBS Next Avenue on what biology tells us about gender and longevity. Austad on sex chromosomes and longevity in The Guardian's article, “The mystery of the lifespan gap between the sexes could be solved,” researchers say.
The Dubal laboratory is determining how the second X chromosome confers neural resilience in aging and disease through mechanisms that allow it to escape the inactivation of the X chromosome and the parent's X imprint. Dubal is an adjunct professor at the UCSF Center for Memory and Aging. Dubal and Emily Davis, an AFAR fellow, have conducted research on cellular aging on XX sex chromosomes that increase survival and extend life expectancy in aging mice. He has studied how a gene called “RICTOR” may be responsible for the differential effects of the drug rapamycin in men and women. The gene is involved in many bodily functions, including growth and development, as well as in diseases such as diabetes and cancer.
He is testing whether sex hormones, such as estrogen and testosterone, influence the action of RICTOR in the liver and if these hormones are important regulators of the longevity of mice. Lamming is an adjunct professor at the University of Wisconsin-Madison. Lamming's research on Rictor and male life expectancy in Aging Cell. Sinclair's research recently published in Cell on the epigeminal, the aging clock and the slowing of aging in mice. Sinclair co-authored research on the inversion of the biological clock that restores vision in old mice.
Sinclair talks about cellular programming on The Drive podcast, with Dr. Peter Attia. Levine is an adjunct professor at the Yale Center for Research on Aging (Y-Age) in the Department of Pathology at the Yale School of Medicine. She is the founder of the Laboratory for the Aging of Living Systems (Levine Lab).
Levine was the lead author of an article published in the journal Aging, an epigenetic biomarker of aging for life expectancy and health. Levine gave a presentation at the Foresight Institute on the standardization of biomarkers.
